| First Author | Ye L | Year | 2019 |
| Journal | Nat Immunol | Volume | 20 |
| Issue | 5 | Pages | 593-601 |
| PubMed ID | 30886417 | Mgi Jnum | J:282454 |
| Mgi Id | MGI:6380985 | Doi | 10.1038/s41590-019-0345-x |
| Citation | Ye L, et al. (2019) Interferon-lambda enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin. Nat Immunol 20(5):593-601 |
| abstractText | Interferon-lambda (IFN-lambda) acts on mucosal epithelial cells and thereby confers direct antiviral protection. In contrast, the role of IFN-lambda in adaptive immunity is far less clear. Here, we report that mice deficient in IFN-lambda signaling exhibited impaired CD8(+) T cell and antibody responses after infection with a live-attenuated influenza virus. Virus-induced release of IFN-lambda triggered the synthesis of thymic stromal lymphopoietin (TSLP) by M cells in the upper airways that, in turn, stimulated migratory dendritic cells and boosted antigen-dependent germinal center reactions in draining lymph nodes. The IFN-lambda-TSLP axis also boosted production of the immunoglobulins IgG1 and IgA after intranasal immunization with influenza virus subunit vaccines and improved survival of mice after challenge with virulent influenza viruses. IFN-lambda did not influence the efficacy of vaccines applied by subcutaneous or intraperitoneal routes, indicating that IFN-lambda plays a vital role in potentiating adaptive immune responses that initiate at mucosal surfaces. |
