| Type | MGI:General | Description | mice develop acute T-cell lymphoblastic leukemia, with 90% of mice becoming sick at 4-8 months of age nearly 100% of cells in the spleen express Ki-67, indicating a very high proliferation index that is characteristic of an aggressive, rapidly growing leukemia the majority of splenic T cells exhibit BrdU incorporation, indicating robust proliferation the majority of malignant cells are immature T-cells expressing TdT and lacking NK1.1 |
