| First Author | Laird RM | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 11 | Pages | 6518-27 |
| PubMed ID | 20974990 | Mgi Jnum | J:167365 |
| Mgi Id | MGI:4868135 | Doi | 10.4049/jimmunol.1002766 |
| Citation | Laird RM, et al. (2010) Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing gammadelta T cells. J Immunol 185(11):6518-27 |
| abstractText | The Ag receptors on alphabeta and gammadelta T cells differ not only in the nature of the ligands that they recognize but also in their signaling potential. We hypothesized that the differences in alphabeta- and gammadeltaTCR signal transduction were due to differences in the intracellular signaling pathways coupled to these two TCRs. To investigate this, we used transcriptional profiling to identify genes encoding signaling molecules that are differentially expressed in mature alphabeta and gammadelta T cell populations. Unexpectedly, we found that B lymphoid kinase (Blk), a Src family kinase expressed primarily in B cells, is expressed in gammadelta T cells but not in alphabeta T cells. Analysis of Blk-deficient mice revealed that Blk is required for the development of IL-17-producing gammadelta T cells. Furthermore, Blk is expressed in lymphoid precursors and, in this capacity, plays a role in regulating thymus cellularity during ontogeny. |
