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Protein Coding Gene : Oga O-GlcNAcase

Primary Identifier  MGI:1932139 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  76055
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable beta-N-acetylglucosaminidase activity; histone acetyltransferase activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of protein metabolic process. Predicted to be located in cytosol. Is expressed in brain; liver; and retina nuclear layer. Orthologous to human OGA (O-GlcNAcase).
PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit perinatal lethality associated with a developmental delay and respiratory failure. Mouse embryonic fibroblasts exhibit proliferative and mitotic defects, frequent cytokinesis failure, and loss of genomic stability. [provided by MGI curators]
  • synonyms:
  • MGI:1923305,
  • mKIAA0679,
  • expressed sequence AA408215,
  • RIKEN cDNA 4833427O07 gene,
  • Mgea5,
  • AA408215,
  • RIKEN cDNA 2810009A20 gene,
  • meningioma expressed antigen 5 (hyaluronidase),
  • Hy5,
  • O-GlcNAcase,
  • MGI:1919887,
  • RIKEN cDNA 5830447M11 gene,
  • 4833427O07Rik,
  • MGI:1921158,
  • Oga,
  • 5830447M11Rik,
  • 2810009A20Rik,
  • MGI:2147432

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