Primary Identifier | MGI:1932139 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 76055 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable beta-N-acetylglucosaminidase activity; histone acetyltransferase activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of protein metabolic process. Predicted to be located in cytosol. Is expressed in brain; liver; and retina nuclear layer. Orthologous to human OGA (O-GlcNAcase). PHENOTYPE: Mice homozygous for a gene-trapped allele exhibit perinatal lethality associated with a developmental delay and respiratory failure. Mouse embryonic fibroblasts exhibit proliferative and mitotic defects, frequent cytokinesis failure, and loss of genomic stability. [provided by MGI curators] |