| First Author | Macé É | Year | 2018 |
| Journal | Neuron | Volume | 100 |
| Issue | 5 | Pages | 1241-1251.e7 |
| PubMed ID | 30521779 | Mgi Jnum | J:268750 |
| Mgi Id | MGI:6268965 | Doi | 10.1016/j.neuron.2018.11.031 |
| Citation | Mace E, et al. (2018) Whole-Brain Functional Ultrasound Imaging Reveals Brain Modules for Visuomotor Integration. Neuron 100(5):1241-1251.e7 |
| abstractText | Large numbers of brain regions are active during behaviors. A high-resolution, brain-wide activity map could identify brain regions involved in specific behaviors. We have developed functional ultrasound imaging to record whole-brain activity in behaving mice at a resolution of approximately 100 mum. We detected 87 active brain regions during visual stimulation that evoked the optokinetic reflex, a visuomotor behavior that stabilizes the gaze both horizontally and vertically. Using a genetic mouse model of congenital nystagmus incapable of generating the horizontal reflex, we identified a subset of regions whose activity was reflex dependent. By blocking eye motion in control animals, we further separated regions whose activity depended on the reflex's motor output. Remarkably, all reflex-dependent but eye motion-independent regions were located in the thalamus. Our work identifies functional modules of brain regions involved in sensorimotor integration and provides an experimental approach to monitor whole-brain activity of mice in normal and disease states. |
