| First Author | Cao S | Year | 2016 |
| Journal | Cell Rep | Volume | 14 |
| Issue | 4 | Pages | 695-707 |
| PubMed ID | 26776522 | Mgi Jnum | J:271350 |
| Mgi Id | MGI:6204559 | Doi | 10.1016/j.celrep.2015.12.070 |
| Citation | Cao S, et al. (2016) The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation. Cell Rep 14(4):695-707 |
| abstractText | Commensal microbes are necessary for a healthy gut immune system. However, the mechanism involving these microbes that establish and maintain gut immune responses is largely unknown. Here, we have found that the gut immune receptor leucine-rich repeat (LRR) C19 is involved in host-microbiota interactions. LRRC19 deficiency not only impairs the gut immune system but also reduces inflammatory responses in gut tissues. We demonstrate that the LRRC19-associated chemokines CCL6, CCL9, CXCL9, and CXCL10 play a critical role in immune cell recruitment and intestinal inflammation. The expression of these chemokines is associated with regenerating islet-derived (REG) protein-mediated microbiotas. We also found that the expression of REGs may be regulated by gut Lactobacillus through LRRC19-mediated activation of NF-kappaB. Therefore, our study establishes a regulatory axis of LRRC19, REGs, altered microbiotas, and chemokines for the recruitment of immune cells and the regulation of intestinal inflammation. |
