| First Author | Zürner M | Year | 2009 |
| Journal | Genomics | Volume | 93 |
| Issue | 3 | Pages | 243-53 |
| PubMed ID | 19013515 | Mgi Jnum | J:146971 |
| Mgi Id | MGI:3839042 | Doi | 10.1016/j.ygeno.2008.10.007 |
| Citation | Zurner M, et al. (2009) The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Genomics 93(3):243-53 |
| abstractText | In the nervous system the Liprin-alpha protein family plays an important role in the regulation of dendrite development, the targeting of photoreceptor axons, and the formation and structure of synapses. To gain a better understanding of Liprin-alpha regulation we have comparatively analyzed the genomic organization of the human and mouse Liprin-alpha genes, characterized the alternative exon use in human and mouse, and studied their expression in adult rodent tissues and brain regions. Our results show that Liprins-alpha1-4 share multiple properties in their genomic structure, exhibit an identical modular organization, and are highly conserved within certain structural domains, indicating strong evolutionary cohesion. We demonstrate that all Liprin-alpha genes are subject to alternative splicing, which is regulated in a developmental manner. Interestingly, regulation via alternative splicing is not conserved between isoforms and across species and represents a post-transcriptional mechanism to independently diversify the properties of the individual isoforms. |
