| First Author | Rehm A | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5057 | PubMed ID | 25266931 |
| Mgi Jnum | J:225343 | Mgi Id | MGI:5692407 |
| Doi | 10.1038/ncomms6057 | Citation | Rehm A, et al. (2014) Dendritic cell-mediated survival signals in Emu-Myc B-cell lymphoma depend on the transcription factor C/EBPbeta. Nat Commun 5:5057 |
| abstractText | The capacity of dendritic cells (DCs) to regulate tumour-specific adaptive immune responses depends on their proper differentiation and homing status. Whereas DC-associated tumour-promoting functions are linked to T-cell tolerance and formation of an inflammatory milieu, DC-mediated direct effects on tumour growth have remained unexplored. Here we show that deletion of DCs substantially delays progression of Myc-driven lymphomas. Lymphoma-exposed DCs upregulate immunomodulatory cytokines, growth factors and the CCAAT/enhancer-binding protein beta (C/EBPbeta). Moreover, Emu-Myc lymphomas induce the preferential translation of the LAP/LAP* isoforms of C/EBPbeta. C/EBPbeta(-/-) DCs are unresponsive to lymphoma-associated cytokine changes and in contrast to wild-type DCs, they are unable to mediate enhanced Emu-Myc lymphoma cell survival. Antigen-specific T-cell proliferation in lymphoma-bearing mice is impaired; however, this immune suppression is reverted by the DC-restricted deletion of C/EBPbeta. Thus, we show that C/EBPbeta-controlled DC functions are critical steps for the creation of a lymphoma growth-promoting and -immunosuppressive niche. |
