| First Author | Luckashenak N | Year | 2008 |
| Journal | Immunity | Volume | 28 |
| Issue | 4 | Pages | 521-32 |
| PubMed ID | 18387832 | Mgi Jnum | J:134512 |
| Mgi Id | MGI:3788994 | Doi | 10.1016/j.immuni.2008.02.018 |
| Citation | Luckashenak N, et al. (2008) Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 28(4):521-32 |
| abstractText | Immature dendritic cells (DCs) sample tissue-specific antigens (TSAs) and process them for 'crosspresentation' via major histocompatibility complex (MHC) class I and II molecules. Findings with adoptively transferred T cell receptor (TCR)-transgenic CD8+ T cells in transgenic mice expressing model TSA indicate that this process contributes to tolerance induction of CD8+ T cells, a phenomenon termed 'crosstolerance.' However, up to now it has been unknown whether 'crosstolerance' can also control autoimmune T cells specific for physiological nontransgenic TSA. Here, we showed that a DC-specific deficiency in uptake of apoptotic material inhibits crosspresentation in vivo. This defect allowed the accumulation of fully functional autoreactive CD8+ T cells that could be activated for autoimmune attack in peripheral lymphoid organs. Thus, our data demonstrate the importance of crosstolerance induction by DCs as a vital instrument for controlling self-reactive T cells from the peripheral repertoire and preventing autoimmune disease. |
