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Protein Coding Gene : Metap2 methionine aminopeptidase 2
Primary Identifier  MGI:1929701 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  56307
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; and telencephalon. Orthologous to human METAP2 (methionyl aminopeptidase 2).
PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality around E8.5, smaller size, failure to gastrulate, reduced cell proliferation and absence of a distinct mesoderm. [provided by MGI curators]
  • synonyms:
  • A930035J23Rik,
  • MGI:2144355,
  • expressed sequence AU014659,
  • AU014659,
  • RIKEN cDNA 4930584B20 gene,
  • AL024412,
  • methionine aminopeptidase 2,
  • expressed sequence AL024412,
  • Metap2,
  • MGI:2144066,
  • 4930584B20Rik,
  • eIF-2-associated p67,
  • p67,
  • MGI:2143717,
  • MGI:1923115,
  • RIKEN cDNA A930035J23 gene,
  • MGI:1925609,
  • expressed sequence AI047573,
  • AI047573
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Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

Trail: ProteinCodingGene

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

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0 Driver For





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