| First Author | Philpott KL | Year | 1992 |
| Journal | Science | Volume | 256 |
| Issue | 5062 | Pages | 1448-52 |
| PubMed ID | 1604321 | Mgi Jnum | J:1292 |
| Mgi Id | MGI:49822 | Doi | 10.1126/science.1604321 |
| Citation | Philpott KL, et al. (1992) Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. Science 256(5062):1448-52 |
| abstractText | Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells. |
