| First Author | Saran A | Year | 2002 |
| Journal | Int J Cancer | Volume | 97 |
| Issue | 5 | Pages | 580-3 |
| PubMed ID | 11807781 | Mgi Jnum | J:74019 |
| Mgi Id | MGI:2157304 | Doi | 10.1002/ijc.10104 |
| Citation | Saran A, et al. (2002) Inhibition of both skin and lung tumorigenesis by Car-R mouse-derived cancer modifier loci. Int J Cancer 97(5):580-3 |
| abstractText | The Car-R outbred mouse line was phenotypically selected for high resistance to two-stage skin tumorigenesis. In the present study we tested the hypothesis that a subset of genetic loci responsible for resistance to skin tumorigenesis of Car-R mice might also inhibit lung tumorigenesis. Skin and lung tumorigenesis were induced in groups of Car-R, SWR/J, (SWR/JxCar-R)F1 and SWR/Jx(SWR/JxCar-R) backcross mice by i.p. urethane initiation and skin TPA promotion. Car-R mice showed a much lower susceptibility to both skin and lung tumorigenesis as compared to SWR/J mice, which are susceptible to both lung and skin tumorigenesis. The Car-R-inherited genome significantly inhibited both skin and lung cancer development in the F1 progeny of Car-R with SWR/J mice. In the backcross population, skin and lung tumor phenotypes showed a statistically significant correlation, indicating that a subset of the cancer resistance alleles, which segregated in the Car-R line during selection for resistance to skin carcinogenesis, provides resistance to both skin and lung tumorigenesis. |
