| First Author | Kelner GS | Year | 1994 |
| Journal | Science | Volume | 266 |
| Issue | 5189 | Pages | 1395-9 |
| PubMed ID | 7973732 | Mgi Jnum | J:29507 |
| Mgi Id | MGI:77040 | Doi | 10.1126/science.7973732 |
| Citation | Kelner GS, et al. (1994) Lymphotactin: a cytokine that represents a new class of chemokine. Science 266(5189):1395-9 |
| abstractText | In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily. |
