| First Author | Kennedy J | Year | 1995 |
| Journal | J Immunol | Volume | 155 |
| Issue | 1 | Pages | 203-9 |
| PubMed ID | 7602097 | Mgi Jnum | J:26196 |
| Mgi Id | MGI:73861 | Doi | 10.4049/jimmunol.155.1.203 |
| Citation | Kennedy J, et al. (1995) Molecular cloning and functional characterization of human lymphotactin. J Immunol 155(1):203-9 |
| abstractText | We describe the isolation of a cDNA that encodes human lymphotactin (Ltn), a new class of lymphocyte-specific chemokine. Human Ltn shows similarity to some members of the C-C chemokine family but has lost the first and third cysteine residues that are characteristic of the C-C and C-X-C chemokines. Ltn is chemotactic for lymphocytes but not for monocytes, a characteristic that makes it unique among chemokines. In addition, calcium flux desensitization studies indicate that Ltn uses a unique receptor. The human Ltn gene maps to a different chromosome than do the C-C and C-X-C chemokine families. Taken together, these characteristics indicate that Ltn is the first example of a new class of human chemokines with preferential effects on lymphocytes. |
