| Primary Identifier | IPR031644 | Type | Domain |
| Short Name | MKRN1_C |
| description | This domain is found at the C terminus of makorins, a family of eukaryotic putative ribonucleoproteins with a distinctive array of zinc-finger motifs []. Makorin-1 (MKRN1) plays an important role in modulating the homeostasis of telomere-length through a dynamic balance involving the stability of the protein hTERT []. MKRN1 has been shown to be a a transcriptional co-regulator and an E3 ligase. It functions simultaneously as a differentially negative regulator of p53 and p21, preferentially leading cells to p53-dependent apoptosis by suppressing p21 []. The exact function of the C-terminal region has not been determined. |
