| First Author | Hermanz-Falcón P | Year | 2001 |
| Journal | Immunogenetics | Volume | 53 |
| Issue | 4 | Pages | 288-95 |
| PubMed ID | 11491532 | Mgi Jnum | J:71137 |
| Mgi Id | MGI:2149226 | Doi | 10.1007/s002510100326 |
| Citation | Hermanz-Falcon P, et al. (2001) Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells. Immunogenetics 53(4):288-95 |
| abstractText | We identified a new Ca2+-dependent lectin-like receptor gene, DECTIN-1 (HGMW-approved symbol CLECSF12), the human orthologue of mouse Dectin-1, coding for a putative type II transmembrane glycoprotein with an extracellular C-type lectin-like domain. The gene structure and two alternative spliced forms of DECTIN-1 are described. The DECTIN-1 gene was localized in the natural killer gene complex on human Chromosome 12p12.3-p13.2, between OLR1 and CD94 (position 21.8 cM on the genetic map). The DECTIN-1 gene is highly expressed at the mRNA level in dendritic cells and is not further up-regulated during the maturation of these cells with tumor necrosis factor-alpha. The DECTIN-1 gene therefore represents a novel human member of the C-type lectin-like receptor gene family preferentially expressed in dendritic cells. |
