Primary Identifier | MGI:3530000 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Prnp-SNCA)20Vle |
Strain of Origin | C57BL/6 x C3H | Is Recombinase | false |
Is Wild Type | false |
description | This transgenic line, originally designated M20, has the highest level of expression. Transgenic lines M7 and M12 were also generated. |
molecularNote | The transgene contains wild-type human alpha synuclein cDNA and the mouse prion protein (Prnp) gene promoter together with its 5' untranslated region (UTR) containing an intron, and its 3' untranslated sequences. Transgene expression was detected in the cerebral cortex, spinal cord, and cerebellum. |