| Primary Identifier | MGI:105094 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 11516 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables pituitary adenylate cyclase activating polypeptide activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; insulin secretion; and positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of cell cycle and positive regulation of gene expression. Predicted to be located in extracellular space and terminal bouton. Predicted to be active in neuron projection and perikaryon. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; embryo mesenchyme; and neural retina. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit high postnatal mortality, impaired thermoregulation, and loss of white fat. Survivors show ketosis, microvesicular fat accumulation, elevated serum lipids, and behavioral abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
