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Comment :

Type  MGI:General Description  hepatocellular carcinoma observed in 60.0% of male mice and in 45.5% of female mice after 18 months of age no metastases were detected HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation