| First Author | Koyuncu H | Year | 1999 |
| Journal | Anticancer Res | Volume | 19 |
| Issue | 4B | Pages | 3237-41 |
| PubMed ID | 10652617 | Mgi Jnum | J:60830 |
| Mgi Id | MGI:1353946 | Citation | Koyuncu H, et al. (1999) Preventive effect of hesperidin against inflammation in CD-1 mouse skin caused by tumor promoter. Anticancer Res 19(4B):3237-41 |
| abstractText | Our earlier studies have shown that the flavonoid hesperidin inhibits tumor promotion in a two stage skin tumorigenesis protocol in CD-1 mice. In this study hesperidin's significant protection (p < 0.0001) against 12-0-tetradecanoylphorbol-13-acetate (TPA) induced edema in CD-1 mouse ear will be presented. Hesperidin also afforded significant protection against TPA induced hyperplasia in the dorsal skin through multiple application prior to TPA. Protection by hesperidin was 93% of the epidermal thickness and 100% of the vertical cell layers. The data also indicate the protective effect of hesperidin against TPA caused infiltration of neutrophils by 73%. These results suggest that hesperidin may possess potential as chemopreventive agent against tumor promoter induced inflammation and hyperplasia. |
