| First Author | McAleer JP | Year | 2011 |
| Journal | Int Immunol | Volume | 23 |
| Issue | 2 | Pages | 129-37 |
| PubMed ID | 21233255 | Mgi Jnum | J:168576 |
| Mgi Id | MGI:4889015 | Doi | 10.1093/intimm/dxq464 |
| Citation | McAleer JP, et al. (2011) The WSX-1 pathway restrains intestinal T-cell immunity. Int Immunol 23(2):129-37 |
| abstractText | Mechanisms regulating intestinal T-cell accumulation during inflammation have considerable therapeutic value. In this study, LPS increased Staphylococcus aureus enterotoxin A-specific T cells in the gut through induction of IL-12 family members. Mice deficient in IL-12 (p35(-/-)) favored T(h)17 differentiation in lamina propria, whereas mice lacking both IL-12 and IL-23 (p40(-/-)) produced significantly fewer T(h)17 cells. However, serum analysis revealed that IL-27p28 was much higher and sustained following LPS injection than other IL-12 family cytokines. Strikingly, WSX-1 (IL-27Ralpha) deficiency resulted in log-fold increases in lamina propria T(h)17 cells without affecting T(h)1 numbers. These results may be explained by increased expression of alpha4beta7 on WSX-1-deficient T cells after immunization. WSX-1-deficient regulatory T cells (Tregs) were also perturbed, producing more IL-17 and less IL-10 than wild-type Tregs. Thus, IL-27 blockade may provide a new pathway to improve mucosal vaccination. |
