| First Author | De Jager PL | Year | 1998 |
| Journal | Genomics | Volume | 48 |
| Issue | 3 | Pages | 346-53 |
| PubMed ID | 9545640 | Mgi Jnum | J:46798 |
| Mgi Id | MGI:1202092 | Doi | 10.1006/geno.1997.5193 |
| Citation | De Jager PL, et al. (1998) A high-resolution genetic map of the nervous locus on mouse chromosome 8. Genomics 48(3):346-53 |
| abstractText | The nervous (nr) mutant mouse displays two gross recessive traits: both an exaggeration of juvenile hyperactivity and a pronounced ataxia become apparent during the third and fourth postnatal weeks. Using an intersubspecific intercross, we have established a high-resolution map of a segment of mouse Chromosome 8 that places the nr locus in a genomic segment defined by D8Rck1 on the centromeric end and D8Mit3 on the telomeric end. This map position places the nr locus within the BALB/cGr congenic region of the C3HeB/FeJ-nr strain, confirming the accuracy of our study. We used this map position to identify and evaluate three genes-ankyrin 1, cortexin, and farnesyltransferase-as candidates for the nr gene. These three genes were eliminated from consideration but allowed us to establish the conservation of synteny between the region containing the nr locus and a segment of the short arm of human chromosome 8 (8p21-p11.2). Finally, the incomplete penetrance of the nr phenotype led us to perform a screen for modifier loci, and we present evidence that such a nervous modifier locus may exist on mouse Chromosome 5. (C) 1998 Academic Press. |
