| First Author | Moon HY | Year | 2014 |
| Journal | Cell Metab | Volume | 20 |
| Issue | 4 | Pages | 560-2 |
| PubMed ID | 25295784 | Mgi Jnum | J:215523 |
| Mgi Id | MGI:5605587 | Doi | 10.1016/j.cmet.2014.09.012 |
| Citation | Moon HY, et al. (2014) Muscle over mind. Cell Metab 20(4):560-2 |
| abstractText | Depression is associated with elevated kynurenine levels, a tryptophan metabolite generated under stress and inflammatory conditions. Agudelo et al. (2014) now reveal how PGC-1alpha1 overexpression in muscle mimics anti-depressant effects of exercise by promoting kynurenine aminotransferase expression, likely preventing kynurenine from crossing the blood brain barrier to disrupt neural plasticity. |
