| Primary Identifier | MGI:1915501 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 68251 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Acts upstream of or within hematopoietic stem cell proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of BRCA1-A complex and BRISC complex. Predicted to be active in nuclear body. Orthologous to human BABAM1 (BRISC and BRCA1 A complex member 1). PHENOTYPE: Mice homozygous for a knock-out allele show thrombocytosis and increased hematopoietic stem cell (HSC) number. HSCs are more resistant to cytotoxic stress and show increased quiescence, decelerated cell cycle kinetics, and enhanced repopulating ability and self-renewal upon serial transplantation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
