| First Author | O'Rourke AM | Year | 1998 |
| Journal | Immunogenetics | Volume | 48 |
| Issue | 5 | Pages | 354-5 |
| PubMed ID | 9745014 | Mgi Jnum | J:50231 |
| Mgi Id | MGI:1290087 | Doi | 10.1007/s002510050444 |
| Citation | O'Rourke AM, et al. (1998) Cloning and sequencing of cDNA encoding mouse cytohesin-1. Immunogenetics 48(5):354-5 |
| abstractText | Lymphocyte function-associated antigen-1 (LFA-1; aL beta 2; CD11a/CD18) is a member of the integrin family of cell surface adhesion receptors, and binds to the widely- expressed intercellular adhesion molecules -1, -2, and -3 (ICAM-1, -2, -3). LFA-1-ICAM interactions play critical roles in T-lymphocyte immune responses, mediating firm adhesion to antigen-presenting cells and target cells and additionally providing co-stimulatory signals for T-cell activation (Diamond and Springer 1994; Gahmberg 1997). The importance of LFA-1-ICAM interactions to cells involved in an immune response is emphasized by the fact that individuals with a CD18 gene defect lack functional cell surface beta 2 chains and suffer from leukocyte adhesion deficiency, a potentially fatal disease characterized by recurrent pathogenic infections (Anderson and Springer 1987). |
