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Protein Coding Gene : Sdhaf4 succinate dehydrogenase complex assembly factor 4
Primary Identifier  MGI:1915252 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  68002
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables enzyme activator activity. Involved in cellular respiration and mitochondrial respiratory chain complex II assembly. Acts upstream of or within innate immune response. Located in mitochondrion. Used to study dilated cardiomyopathy. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4).
PHENOTYPE: Mice with conditional loss of expression in the heart display premature lethality, dilated cardiomyopathy, and myocardial mitochondrial abnormalities. [provided by MGI curators]
  • synonyms:
  • MGI:1922711,
  • 1700001E18Rik,
  • RIKEN cDNA 1110058L19 gene,
  • succinate dehydrogenase complex assembly factor 4,
  • AI847425,
  • MGI:2138344,
  • expressed sequence AI847425,
  • 1110058L19Rik,
  • RIKEN cDNA 1700001E18 gene,
  • Sdhaf4
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1 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

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4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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