Primary Identifier | MGI:1919818 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 72568 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable DNA binding activity. Predicted to be involved in regulation of cell cycle; regulation of transcription by RNA polymerase II; and reproduction. Predicted to act upstream of or within DNA biosynthetic process. Predicted to be located in nucleus. Predicted to be part of transcription repressor complex. Predicted to be active in nucleoplasm. Is expressed in telencephalon ventricular layer. Orthologous to human LIN9 (lin-9 DREAM MuvB core complex component). PHENOTYPE: Mice homozygous for a knock-out allele show increased body weight. Mice homozygous for a gene-trap allele die shortly after implantation with defects in early embryogenesis. Homozygous deletion in adult mice causes premature death, intestinal epithelium atrophy, and abnormal mitosis. [provided by MGI curators] |