Primary Identifier | MGI:88264 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 12334 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables calcium-dependent cysteine-type endopeptidase activity. Involved in cellular response to amino acid stimulus and proteolysis. Acts upstream of or within blastocyst development and myoblast fusion. Located in cytosol; lysosome; and nucleus. Part of chromatin. Is expressed in several structures, including central nervous system; lens epithelium; molar; oral region epithelium; and skin. Orthologous to human CAPN2 (calpain 2). PHENOTYPE: Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure. [provided by MGI curators] |