Primary Identifier | MGI:2148258 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 111174 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables trace-amine receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Used to study schizophrenia. Orthologous to human TAAR1 (trace amine associated receptor 1). PHENOTYPE: Mice homozygous for a null mutation display decreased prepulse inhibition and increased sensitivity to amphetamines. Mice homozygous for another knock-out allele exhibit increased sensitivity to MDMA-induced hyperthermia, brain dopamine and serotonin levels, and induced hyperactivity. [provided by MGI curators] |