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Protein Coding Gene : Hdac2 histone deacetylase 2

Primary Identifier  MGI:1097691 Organism  Mus musculus
Chromosome  10 NCBI Gene Number  15182
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits several functions, including DNA binding activity; Krueppel-associated box domain binding activity; and RNA polymerase II transcription corepressor binding activity. Involved in several processes, including animal organ development; histone modification; and regulation of cell development. Localizes to RNA polymerase II transcription repressor complex and chromosome. Is expressed in several structures, including early conceptus; genitourinary system; intestine; nervous system; and retina. Human ortholog(s) of this gene implicated in stomach cancer. Orthologous to human HDAC2 (histone deacetylase 2).
PHENOTYPE: Mice homozygous for a null allele exhibit embryonic and postnatal lethality accompanied with a transient decrease in body size and increase in heart size and cardiomyocyte proliferation that is overcome by 2 months of age in surviving mice. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-36452,
  • histone deacetylase 2,
  • Hdac2,
  • DNA segment, Chr 10, Wayne State University 179, expressed,
  • YY1 transcription factor binding protein,
  • MGI:107875,
  • Yy1bp,
  • D10Wsu179e

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

27 Pathways

295 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications