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Protein Coding Gene : Fyn Fyn proto-oncogene

Primary Identifier  MGI:95602 Organism  Mus musculus
Chromosome  10 NCBI Gene Number  14360
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Exhibits several functions, including cytoskeletal protein binding activity; ion channel binding activity; and protein tyrosine kinase activity. Involved in several processes, including negative regulation of macromolecule metabolic process; nervous system development; and regulation of signal transduction. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; actin filament; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).
PHENOTYPE: Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation. [provided by MGI curators]
  • synonyms:
  • AW552119,
  • Fyn,
  • AI448320,
  • Src Kinase p59,
  • expressed sequence AI448320,
  • Fyn proto-oncogene,
  • MGI:2143602,
  • MGD-MRK-9909,
  • MGI:2143864,
  • expressed sequence AW552119

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

6 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

62 Pathways

480 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications