| Primary Identifier | MGI:1351646 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 27403 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables apolipoprotein A-I receptor activity and phospholipid transporter activity. Involved in several processes, including learning or memory; positive regulation of transport; and regulation of MAPK cascade. Acts upstream of or within phospholipid efflux. Located in several cellular components, including apical plasma membrane; phagocytic cup; and ruffle membrane. Is expressed in several structures, including alimentary system; hemolymphoid system; integumental system; nervous system; and nose. Human ortholog(s) of this gene implicated in Alzheimer's disease 9. Orthologous to human ABCA7 (ATP binding cassette subfamily A member 7). PHENOTYPE: Homozygous mutant females, but not males, have less white fat and lower total serum and HDL cholesterol levels. Males exhibit a 10% reduction in kidney size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
