Primary Identifier | MGI:1916536 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 69286 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Acts upstream of or within binding activity of sperm to zona pellucida. Located in acrosomal vesicle and sperm connecting piece. Part of protein complex involved in cell-cell adhesion. Orthologous to human GLIPR1L1 (GLIPR1 like 1). PHENOTYPE: Homozygous knock-out males exhibit spermatozoa with reduced ability to undergo an acrosome reaction and impaired sperm-oocyte fusion, however males show normal fertility in vivo. [provided by MGI curators] |