| Primary Identifier | MGI:1353578 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 30939 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables cysteine-type endopeptidase inhibitor activity. Acts upstream of or within homologous chromosome segregation and mitotic sister chromatid cohesion. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; limb; mesonephric tubule of male; and testis. Orthologous to several human genes including PTTG1 (PTTG1 regulator of sister chromatid separation, securin). PHENOTYPE: Mice homozygous for a knock-out allele show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, chromosome instability, premature centromere division, reduced female fertility, reduced pancreatic betacell mass and sexually-dimorphic diabetes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
