| Primary Identifier | MGI:1342292 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 15525 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and adenyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; negative regulation of macromolecule metabolic process; and protein insertion into mitochondrial outer membrane. Predicted to be located in extracellular exosome and lipid droplet. Predicted to be active in cytosol and nucleus. Is expressed in cerebral cortex and genitourinary system. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). PHENOTYPE: Mice homozygous for a knock-out allele exhibit age-dependent neurofibrillary tangles and tau deposits, impaired contextual conditioning, and impaired bar grasping. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
