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Protein Coding Gene : Tnip1 TNFAIP3 interacting protein 1

Primary Identifier  MGI:1926194 Organism  Mus musculus
Chromosome  11 NCBI Gene Number  57783
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1.1)

Exhibits polyubiquitin modification-dependent protein binding activity. Involved in several processes, including MyD88-dependent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of transcription by RNA polymerase II. Localizes to cytoplasm. Is expressed in gonad; ovary; seminiferous cord; and thymus primordium. Orthologous to human TNIP1 (TNFAIP3 interacting protein 1).
PHENOTYPE: Mice homozygous for a null allele exhibit perinatal lethality associated with anemia and focal apoptosis in the fetal liver. Mice homozygous for a gene trap allele exhibit partial prenatal lethality and SLE-like inflammatory disease. [provided by MGI curators]
  • synonyms:
  • TNFAIP3 interacting protein 1,
  • expressed sequence AU018810,
  • AU018810,
  • ABIN1,
  • VAN,
  • MGI:2144384,
  • Tnip1,
  • A20-binding inhibitor of NF-kappa B activation,
  • Nef

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

166 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications