| Primary Identifier | MGI:99403 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 11541 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled adenosine receptor signaling pathway and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including positive regulation of chronic inflammatory response to non-antigenic stimulus; positive regulation of cytokine production; and relaxation of vascular associated smooth muscle. Located in plasma membrane and presynapse. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). PHENOTYPE: Homozygous mutation of this gene results in low-grade inflammation, augmentation of proinflammatory cytokines and increased leukocyte adhesion to the vasculature. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
