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Protein Coding Gene : Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12
Primary Identifier  MGI:1196259 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  21944
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable receptor ligand activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in extracellular region. Is expressed in Meckel's cartilage; limb; skeleton; and superior cervical ganglion. Orthologous to several human genes including TNFSF12 (TNF superfamily member 12).
PHENOTYPE: Mice homozygous for disruptions in this gene have increased numbers of natural killer cells, particulalry in secondary lymph organs. They display an enhanced inflammatory response, increased susceptibility to lipopolysaccharide, and increased tumor resistance. [provided by MGI curators]
  • synonyms:
  • Tweak,
  • Tnfsf12,
  • DR3L,
  • APO3L,
  • tumor necrosis factor (ligand) superfamily, member 12,
  • TNF-related weak inducer of apoptosis
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Features --> Cross References

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Mouse features --> Functions (GO terms)

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Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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