| Primary Identifier | MGI:1261758 | Organism | Mus musculus |
| Chromosome | 11 | NCBI Gene Number | 52615 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1) Exhibits nucleic acid binding activity and promoter-specific chromatin binding activity. Predicted to contribute to histone methyltransferase activity (H3-K27 specific). Involved in several processes, including histone modification; negative regulation of transcription by RNA polymerase II; and oligodendrocyte differentiation. Localizes to nucleus; protein-DNA complex; and ribonucleoprotein complex. Is expressed in several structures, including bone; central nervous system; genitourinary system; limb; and neural retina. Orthologous to human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). PHENOTYPE: Homozygous null mice die during early postimplantation stages with failure of embryonic and extraembyronic tissues and organogenesis. Mice heterozygous for a knock-out allele exhibit abnormal brain and spinal cord development with varying penetrance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
