Primary Identifier | MGI:1927168 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 56405 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; and protein tyrosine phosphatase activity. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human DUSP14 (dual specificity phosphatase 14). PHENOTYPE: Homozygous KO results in increased T cell activation, proliferation and differentiation. It also causes increased cardiac hypertrophy in response to aortic banding. [provided by MGI curators] |