| Primary Identifier | MGI:104327 | Organism | Mus musculus |
| Chromosome | 11 | NCBI Gene Number | 18121 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.2) Predicted to have cytokine binding activity and protein homodimerization activity. Involved in several processes, including animal organ development; chordate embryonic development; and negative regulation of signal transduction. Localizes to extracellular space. Is expressed in several structures, including branchial arch; craniocervical region bone; limb; neural ectoderm; and respiratory system. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism. Orthologous to human NOG (noggin). PHENOTYPE: Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
