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Protein Coding Gene : Nog noggin

Primary Identifier  MGI:104327 Organism  Mus musculus
Chromosome  11 NCBI Gene Number  18121
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.2)

Predicted to have cytokine binding activity and protein homodimerization activity. Involved in several processes, including animal organ development; chordate embryonic development; and negative regulation of signal transduction. Localizes to extracellular space. Is expressed in several structures, including branchial arch; craniocervical region bone; limb; neural ectoderm; and respiratory system. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism. Orthologous to human NOG (noggin).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth. [provided by MGI curators]
  • synonyms:
  • Nog,
  • MGD-MRK-25655,
  • noggin

Features --> Cross References


Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

4 Involved In Mutations

0 Strain

0 Transcripts

5 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features


Gene --> Proteins


Mouse features --> Functions (GO terms)


Genes --> Homologs


3 Pathways

313 Targeted By

Gene --> Protein-Protein Interactions


Gene --> Expression annotations


Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles


Mouse features --> Human diseases


Mouse features --> Publications