| Primary Identifier | MGI:97724 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18948 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables phenylethanolamine N-methyltransferase activity. Predicted to be involved in epinephrine biosynthetic process and norepinephrine metabolic process. Predicted to act upstream of or within catecholamine biosynthetic process and methylation. Predicted to be located in axon; dendrite; and perikaryon. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; gonad; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). PHENOTYPE: Homozygous null mice lack adrenal epinephrine and have increased adrenal norepinephrine levels but are viable and fertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
