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Protein Coding Gene : Grb2 growth factor receptor bound protein 2

Primary Identifier  MGI:95805 Organism  Mus musculus
Chromosome  11 NCBI Gene Number  14784
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 3.1)

Exhibits several functions, including ephrin receptor binding activity; protein phosphatase binding activity; and protein-macromolecule adaptor activity. Involved in several processes, including branching involved in labyrinthine layer morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Localizes to several cellular components, including COP9 signalosome; cell-cell junction; and vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and lung. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2).
PHENOTYPE: Embryos homozygous for a targeted null mutation lack expanded inner cell masses, show only a few endodermal cells, and die by embryonic day 7.5. Heterozygotes have defective T cell signaling and lack the cardiac hypertrophy response to pressure overload. [provided by MGI curators]
  • synonyms:
  • expressed sequence AA408164,
  • MGI:2143976,
  • AA408164,
  • Grb2,
  • MGD-MRK-10242,
  • growth factor receptor bound protein 2

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

120 Pathways

343 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Mouse features --> Alleles

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications