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Protein Coding Gene : Hbp1 high mobility group box transcription factor 1

Primary Identifier  MGI:894659 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  73389
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of lipid transport and negative regulation of reactive oxygen species biosynthetic process. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and neural retina. Orthologous to human HBP1 (HMG-box transcription factor 1).
PHENOTYPE: Mice heterozygous for a gene trapped allele have behavioral abnormalities and show alterations in leukocyte, platelet and NK cell number, blood urea nitrogen levels, and circulating amylase and calcium levels. [provided by MGI curators]
  • synonyms:
  • expressed sequence BE629963,
  • MGI:3034670,
  • 1700058O05Rik,
  • RIKEN cDNA C330012F01 gene,
  • expressed sequence C86454,
  • Hbp1,
  • RIKEN cDNA 1700058O05 gene,
  • high mobility group box transcription factor 1,
  • MGI:1924485,
  • C330012F01Rik,
  • C86454,
  • BE629963,
  • MGI:3034710,
  • MGI:1920639

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