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Protein Coding Gene : Pax9 paired box 9

Primary Identifier  MGI:97493 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  18511
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including face morphogenesis; odontogenesis; and regulation of odontogenesis. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and nose. Used to study tooth agenesis. Human ortholog(s) of this gene implicated in tooth agenesis. Orthologous to human PAX9 (paired box 9).
PHENOTYPE: Homozygous inactivation of this gene results in abnormal tooth development and absent teeth and may lead to lack of pharyngeal pouch derivatives, athymia, craniofacial and limb anomalies, a small tympanic ring, various defects of the skeleton and musculature, and neonatal lethality. [provided by MGI curators]
  • synonyms:
  • Pax-9,
  • paired box 9,
  • MGD-MRK-13161,
  • Pax9,
  • MGD-MRK-13152

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

2 Driver For