| Primary Identifier | MGI:107423 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 18222 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables alpha-catenin binding activity; beta-catenin binding activity; and cadherin binding activity. Involved in forebrain development; positive regulation of neurogenesis; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; nervous system development; and positive regulation of polarized epithelial cell differentiation. Located in several cellular components, including basolateral plasma membrane; clathrin-coated pit; and early endosome. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and thymus. Orthologous to human NUMB (NUMB endocytic adaptor protein). PHENOTYPE: Mice homozygous for a null allele die at ~E11.5 with neural tube closure defects and precocious cortical neurogenesis. Mice homozygous for another null allele show impaired axial rotation, neural tube closure, angiogenic remodeling, placenta formation, and motor and sensory neuron differentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
