Primary Identifier | MGI:2385618 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 105450 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to be an extracellular matrix structural constituent. Involved in cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and positive regulation of defense response to bacterium. Located in basement membrane. Is expressed in several structures, including cardiovascular system; early conceptus; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human MMRN2 (multimerin 2). PHENOTYPE: Mice homozygous for a null allele display abnormal blood vessel morphology, vascular leakage, and increased density of small vessels in tumors. [provided by MGI curators] |