| Primary Identifier | MGI:1891837 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 56373 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables carboxypeptidase activity. Predicted to be involved in several processes, including negative regulation of hepatocyte proliferation; negative regulation of plasminogen activation; and regulation of blood coagulation. Predicted to act upstream of or within blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; liver; and skeleton. Human ortholog(s) of this gene implicated in chronic kidney disease. Orthologous to human CPB2 (carboxypeptidase B2). PHENOTYPE: Homozygous null mice exhibit altered plasma clot lysis and may show reduced bleomycin-induced lung fibrosis, impaired healing of cutaneous wounds and colonic anastomoses, altered glomerular structure, or complement-mediated lethal inflammation after LPS sensitization. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
