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Protein Coding Gene : Acod1 aconitate decarboxylase 1
Primary Identifier  MGI:103206 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  16365
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables aconitate decarboxylase activity and protein homodimerization activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of defense response. Acts upstream of or within response to lipopolysaccharide. Located in mitochondrion. Orthologous to human ACOD1 (aconitate decarboxylase 1).
PHENOTYPE: LPS-stimulated bone marrow macrophages derived from homozygous null mice fail to produce itaconate and exhibit significantly decreased succinate accumulation. [provided by MGI curators]
  • synonyms:
  • expressed sequence AI323667,
  • AI323667,
  • immunoresponsive gene 1,
  • Irg1,
  • MGI:2145617,
  • MGD-MRK-24074,
  • Acod1,
  • aconitate decarboxylase 1
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1 Involved In Mutations

Trail: ProteinCodingGene

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