| Primary Identifier | MGI:104311 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 19219 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; cellular response to mechanical stimulus; and regulation of cytokine production. Acts upstream of or within several processes, including regulation of ossification; response to lipopolysaccharide; and response to nematode. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including arterial system; central nervous system; genitourinary system; heart valve; and skin. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). PHENOTYPE: Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
